Developmental specification of forebrain cholinergic neurons

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• 作者：Kathryn C. Allaway ; Robert Machold ; ^{robert.machold@med.nyu.edu}
• 关键词：Cholinergic ; Striatal interneurons ; Basal forebrain ; Nucleus basalis ; Projection neurons
• 刊名：Developmental Biology
• 出版年：2017
• 出版时间：1 January 2017
• 年：2017
• 卷：421
• 期：1
• 页码：1-7
• 全文大小：567 K
• 卷排序：421

文摘

Striatal cholinergic interneurons and basal forebrain cholinergic projection neurons, which together comprise the forebrain cholinergic system, regulate attention, memory, reward pathways, and motor activity through the neuromodulation of multiple brain circuits. In this review we summarize the transcription factors and signaling molecules known to play a role in the specification and early development of striatal and basal forebrain cholinergic neurons. We also discuss the heterogeneity of these populations and its possible developmental origins.