Toxicogenomic profile of apoptotic and necrotic SN56 basal forebrain cholinergic neuronal loss after acute and long-term chlorpyrifos exposure

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• 作者：Paula Moyano^b ; ¹ ; Javier del Pino^a ; ¹ ; ^{jdelpino@pdi.ucm.es} ; Marí ; a José ; Anadon^b ; Marí ; a Jesú ; s Dí ; az^a ; Gloria Gó ; mez^b ; Marí ; a Teresa Frejo^a
• 关键词：Basal forebrain cholinergic neurons ; Chlorpyrifos ; Necrosis ; Apoptosis ; NOAEL ; Toxicogenomic profile
• 刊名：Neurotoxicology and Teratology
• 出版年：2017
• 出版时间：January-February 2017
• 年：2017
• 卷：59
• 期：Complete
• 页码：68-73
• 全文大小：564 K
• 卷排序：59

文摘

CPF induces apoptotic and necrotic cell death on basal forebrain cholinergic neurons. CPF could induce cell death through extrinsic pathway. Cell death is partially mediated by AChE overexpression. CPF LOATEL was at least 100-fold lower than the concentration needed to AChE inhibition. KChIP1 overexpression after CPF exposure could be a protective mechanism against necrosis.