Contraction and stress-dependent growth shape the forebrain of the early chicken embryo

详细信息    查看全文

• 作者：Kara E. Garcia^a ; ^{karaellspermann@wustl.edu} ; Ruth J. Okamoto^b ; Philip V. Bayly^a ; ^b ; Larry A. Taber^a ; ^b
• 关键词：Brain ; Development ; Actomyosin ; Mechanical feedback ; Cerebrospinal fluid ; Morphogenesis
• 刊名：Journal of the Mechanical Behavior of Biomedical Materials
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：65
• 期：Complete
• 页码：383-397
• 全文大小：3043 K
• 卷排序：65

文摘

The embryonic brain forms distinct sulci that physically divide forebrain regions. Forebrain sulci are initiated by differential patterns of actomyosin contraction. Forebrain sulci deepen during subsequent brain expansion under pressure. Stress-dependent growth predicts forebrain morphogenesis with and without pressure. Constrained growth may explain brain flexure and contribute to growth patterns.