Real-time studies of conformational dynamics of the repair enzyme E. coli formamidopyrimidine-DNA glycosylase and its DNA complexes during catalytic cycle

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• 作者：Vladimir V. Koval ; Nikita A. Kuznetsov ; Alex ; er A. Ishchenko ; Murat K. Saparbaev ; Olga S. Fedorova
• 关键词：Conformational dynamics ; Fpg ; Formamidopyrimidine-DNA glycosylase
• 刊名：Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis
• 出版年：2010
• 出版时间：1 March 2010
• 年：2010
• 卷：685
• 期：1-2
• 页码：3-10
• 全文大小：499 K

文摘

Fpg protein from Escherichia coli belongs to the class of DNA glycosylases/abasic site lyases excising several oxidatively damaged purines in the base excision repair pathway. In this review, we summarize the results of our studies of Fpg protein from E. coli, elucidating the intrinsic mechanism of recognition and excision of damaged bases in DNA.