One Ring to Fight Them All: The Sulfazecin Story

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• 作者：Daniel Braga¹ ; Gerald Lackner¹ ; ^{gerald.lackner@uni-jena.de}
• 刊名：Cell Chemical Biology
• 出版年：2017
• 出版时间：19 January 2017
• 年：2017
• 卷：24
• 期：1
• 页码：1-2
• 全文大小：98 K
• 卷排序：24

文摘

In this issue of Cell Chemical Biology, Li et al. (2017) report on the biosynthesis of the monobactam sulfazecin by Pseudomonas acidophila and hypothesize a novel mechanism of β-lactam ring formation. As monobactam antibiotics are unaffected by some emerging resistance mechanisms (particularly metallo-β-lactamases), this discovery opens prospects to engineer β-lactam antibiotics against multi-drug resistant pathogens.