Autoimmunity—Basics and link with periodontal disease

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• 作者：Gagandeep Kaur^a ; ^{doctorgagandeep@gmail.com} ; Kanika Mohindra^b ; ^{mohindrakanika@gmail.com} ; Shifali Singla^c ; ^{shifali88@gmail.com}
• 关键词：Autoimmunity ; Periodontal disease ; Antibodies ; Immunopathology
• 刊名：Autoimmunity Reviews
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：16
• 期：1
• 页码：64-71
• 全文大小：281 K
• 卷排序：16

文摘

Autoimmune reactions reflect an imbalance between effector and regulatory immune responses, typically develop through stages of initiation and propagation, and often show phases of resolution (indicated by clinical remissions) and exacerbations (indicated by symptomatic flares). The fundamental underlying mechanism of autoimmunity is defective elimination and/or control of self-reactive lymphocytes. Periodontal diseases are characterized by inflammatory conditions that directly affect teeth-supporting structures, which are the major cause of tooth loss. Several studies have demonstrated the involvement of autoimmune responses in periodontal disease. Evidence of involvement of immunopathology has been reported in periodontal disease. Bacteria in the dental plaque induce antibody formation. Autoreactive T-cells, natural killer cells, ANCA, heat shock proteins, autoantibodies, and genetic factors are reported to have an important role in the autoimmune component of periodontal disease. The present review describes the involvement of autoimmune responses in periodontal diseases and also the mechanisms underlying these responses.