Surface stress properties of DNA-microcantilever systems

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• 作者：Zouqing Tan^a ; Nenghui Zhang^a ; ^b ; ^{nhzhang@shu.edu.cn" class="auth_mail} ; Jingjing Li^a ; ^b
• 关键词：surface stress ; DNA hybridization ; microcantilever biosensor ; energy method ; biomolecular interaction
• 刊名：Acta Mechanica Solida Sinica
• 出版年：April 2014
• 年：2014
• 卷：27
• 期：2
• 页码：122-128
• 全文大小：334 K

文摘

For the first time, the connection between surface stress and nanoscopic interactions of DNA adsorbed on microcantilever is established by combining Strey's mesoscopic liquid crystal theory and Stoney's formula. It is shown that surface stress depends not only on biomolecular interactions of DNA biofilm but also on mechanical properties of cantilever. Considering the correlativity between grafting density and chain length of DNA chain, we discuss the differences between DNA-microcantilever system and DNA solution system. The major theoretical achievement of this model is to identify the main contributions to surface stress under different detection conditions. This provides guidelines for designing new biosensors with high sensitivity and improved reliability.