Striatal dopamine D2 binding is related to frontal BOLD response during updating of long-term memory representations

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• 作者：Lars Nyberg ; Micael Andersson ; Lars Forsgren ; Susanna Jakobsson-Mo ; Anne Larsson ; Petter Marklund ; Lars-Gö ; ran Nilsson ; Katrine Riklund ; Lars Bä ; ckman
• 刊名：NeuroImage
• 出版年：2009
• 出版时间：15 July 2009
• 年：2009
• 卷：46
• 期：4
• 页码：1194-1199
• 全文大小：401 K

文摘

Multi-modal brain imaging was used to examine the relation between individual differences in resting-state striatal dopamine D2 binding and the magnitude of prefrontal BOLD activation during updating of long-term memory (LTM) representations. Increased activity in the left prefrontal cortex was observed when LTM updating was required, and there was a positive correlation between striatal D2 activity and the magnitude of left prefrontal activity during updating. These findings support predictions from neurocomputational models of a relation of dopaminergic neurotransmission to transient cognitive operations and related brain activity.