A simple method for noninvasive estimation of pulmonary vascular resistance

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• 作者：Amr E. Abbas ; F. David Fortuin ; Nelson B. Schiller ; Christopher P. Appleton ; Carlos A. Moreno ; Steven J. Lester
• 关键词：AHA/ACC ; Conference Proceedings ; myocardial infarction ; acute ; diagnosis ; treatment
• 刊名：Journal of the American College of Cardiology
• 出版年：2003
• 出版时间：19 March 2003
• 年：2003
• 卷：41
• 期：6
• 页码：1021-1027
• 全文大小：245 K

文摘

We sought to test whether the ratio of peak tricuspid regurgitant velocity (TRV, ms) to the right ventricular outflow tract time-velocity integral (TVI_RVOT, cm) obtained by Doppler echocardiography (TRV/TVI_RVOT) provides a clinically reliable method to determine pulmonary vascular resistance (PVR).

Background

Pulmonary vascular resistance is an important hemodynamic variable used in the management of patients with cardiovascular and pulmonary disease. Right-heart catheterization, with its associated disadvantages, is required to determine PVR. However, a reliable noninvasive method is unavailable.

Methods

Simultaneous Doppler echocardiographic examination and right-heart catheterization were performed in 44 patients. The ratio of TRV/TVI_RVOT was then correlated with invasive PVR measurements using regression analysis. An equation was modeled to calculate PVR in Wood units (WU) using echocardiography, and the results were compared with invasive PVR measurements using the Bland-Altman analysis. Using receiver-operating characteristics curve analysis, a cutoff value for the Doppler equation was generated to determine PVR >2WU.

Results

As calculated by Doppler echocardiography, TRV/TVI_RVOT correlated well (r = 0.929, 95 % confidence interval 0.87 to 0.96) with invasive PVR measurements. The Bland-Altman analysis between PVR obtained invasively and that by echocardiography, using the equation: PVR = TRV/TVI_RVOT × 10 + 0.16 , showed satisfactory limits of agreement (mean 0 ± 0.41). A TRV/TVI_RVOT cutoff value of 0.175 had a sensitivity of 77 % and a specificity of 81 % to determine PVR >2WU.

Conclusions

Doppler echocardiography may provide a reliable, noninvasive method to determine PVR.