Long-term ethanol self-administration induces ΔFosB in male and female adolescent, but not in adult, Wistar rats
文摘
Adolescent, but not adult, rats exhibited escalation of ethanol intake. Ethanol intake induced ΔFosB, particularly at AcbC, AcbSh, BLA and DMS. Adolescents exhibited greater ΔFosB induction, compared to adults, at most areas. Females exhibited greater ΔFosB induction, compared to males, at most areas. Adolescents and adults exhibited similar ethanol-induced stimulation and anxiety.