Contrasting effect of new HCMV pUL54 mutations on antiviral drug susceptibility: Benefits and limits of 3D analysis
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- 作者：D. Andouarda ; b ; c ; M.-C. Mazerond ; G. Ligata ; b ; c ; A. Couvreuxa ; b ; c ; C. Pouteil-Noblee ; R. Cahene ; Y. Yasdanpanahf ; M. Deeringa ; b ; c ; N. Vigetg ; S. Alaina ; b ; c ; S. Hantza ; b ; c ; sebastien.hantz@unilim.fr" class="auth_mail" title="E-mail the corresponding author
- 关键词：Cytomegalovirus ; Resistance ; BAC ; 3D-model ; Ganciclovir ; Foscarnet
- 刊名：Antiviral Research
- 出版年：2016
- 出版时间：May 2016
- 年：2016
- 卷：129
- 期：Complete
- 页码：115-119
- 全文大小：1198 K
文摘
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We characterized two previously unknown HCMV UL54 single point mutations found in immunocompromised patients.
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Both mutations induce resistance to ganciclovir and foscarnet, without impact the viral growth kinetics.
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UL54 3D theoretical model allows a better understanding impact of mutations on protein function and resistance mechanism.