Improving sensitivity and specificity of capturing and detecting targeted cancer cells with anti-biofouling polymer coated magnetic iron oxide nanoparticles

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• 作者：Run Lin^a ; ^b ; ¹ ; Yuancheng Li^a ; ¹ ; Tobey MacDonald^c ; Hui Wu^a ; James Provenzale^d ; Xingui Peng^a ; ^e ; Jing Huang^a ; Liya Wang^a ; Andrew Y. Wang^f ; Jianyong Yang^b ; Hui Mao^a ; ^{hmao@emory.edu}
• 关键词：Magnetic nanoparticles ; Cell separation ; Anti-biofouling ; Circulating tumor cells ; Targeting
• 刊名：Colloids and Surfaces B: Biointerfaces
• 出版年：2017
• 出版时间：1 February 2017
• 年：2017
• 卷：150
• 期：Complete
• 页码：261-270
• 全文大小：2140 K
• 卷排序：150

文摘

Anti-fouling IONPs retain targeting capability upon the exposure to medium protein. IONPs are more sensitive and specific to targeted cells with anti-fouling coating. Anti-fouling IONPs have higher efficiency in targeted cell separation than Dynabeads.