Retreatment with aromatase inhibitor therapy in the management of granulosa cell tumor
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- 作者：Melissa Schwartz ; Gloria S. Huang ; ghuang@montefiore.org" class="auth_mail" title="E-mail the corresponding author
- 关键词：Adult granulosa cell tumor of the ovary ; Aromatase inhibitors ; Letrozole ; FOXL2 ; Antineoplastic hormonal agents ; Statins
- 刊名：Gynecologic Oncology Reports
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：15
- 期：Complete
- 页码：20-21
- 全文大小：155 K
文摘
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Over 90% of granulosa cell tumors have a FOXL2 mutation that contributes to aromatase upregulation.
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Chemotherapy has demonstrated limited efficacy in the treatment of granulosa cell tumors.
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A patient with recurrent granulosa cell tumor responded briefly to anastrazole treatment.
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Retreatment with another aromatase inhibitor letrozole led to a durable response of 24 months.