DNA methylation level of cyp19a1a and Foxl2 gene related to their expression patterns and reproduction traits during ovary development stages of Japanese flounder (Paralichthys olivaceus)
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- 作者：Yufeng Si1 ; Yuxia Ding1 ; Feng He ; hefengouc@ouc.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Haishen Wen ; Jifang Li ; Junli Zhao ; Zhengju Huang
- 关键词：cyp19a1a ; Cytochrome P450 19a1a ; Foxl2 ; Forkhead box L2 ; E2 ; estradiol-17β ; CRE ; cAMP-responsive element ; Ad4BP ; Ad4 binding protein
- 刊名：Gene
- 出版年：2016
- 出版时间：10 January 2016
- 年：2016
- 卷：575
- 期：2
- 页码：321-330
- 全文大小：2303 K
文摘
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The expression of cyp19a1a and Foxl2 change with the ovarian development.
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Methylation levels are negatively correlated with gene expression and steroid level.
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Foxl2 regulates cyp19a1a through forkhead domain binding to cyp19a1a.
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Foxl2 and cyp19a1a are crucial in ovarian development.
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Epigenetic regulation of the genes could play a role in reproductive endocrinology.