A tumor-suppressive microRNA, miR-504, inhibits cell proliferation and promotes apoptosis by targeting FOXP1 in human glioma
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- 作者：Run Cuia ; 1 ; Yanlei Guana ; 1 ; Chuanqi Sunb ; Ling Chenc ; Yijun Baoa ; Guangyu Lia ; Bo Qiua ; Xin Mengd ; Chao Panga ; Yunjie Wanga ; wangyunjie_024@sina.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Glioma ; microRNA ; miR-504 ; Forkhead box protein P1 ; Downregulation
- 刊名：Cancer Letters
- 出版年：2016
- 出版时间：28 April 2016
- 年：2016
- 卷：374
- 期：1
- 页码：1-11
- 全文大小：3116 K
文摘
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MiR-504 downregulation correlated with aggressive clinicopathological features and poor survival in glioma patients.
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MiR-504 suppresses glioma tumorigenicity both in vitro and in vivo.
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MiR-504 regulated glioma tumorigenesis by downregulating expression of its direct target, FOXP1.
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MiR-504 might function as an important tumor suppressor of glioma tumorigenesis.