Tumor necrosis factor reduces Plasmodium falciparum growth and activates calcium signaling in human malaria parasites
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- 作者：Laura N. Cruza ; Yang Wub ; Henning Ulrichc ; Alister G. Craigb ; Cé ; lia R.S. Garciaa ; cgarcia@usp.br" class="auth_mail" title="E-mail the corresponding author
- 关键词：Malaria ; Cytoadhesion ; Tumor necrosis factor ; Plasmodium falciparum ; Calcium signaling ; Proliferating cell nuclear antigen-1
- 刊名：Biochimica et Biophysica Acta (BBA) - General Subjects
- 出版年：2016
- 出版时间：July 2016
- 年：2016
- 卷：1860
- 期：7
- 页码：1489-1497
- 全文大小：1418 K
文摘
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TNF is able to decrease parasitemia in P. falciparum‐infected RBCs.
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TNF induced rises in intracellular calcium concentration, which were blocked by the purinergic receptor agonists KN62 and A438079.
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Interfering with intra‐ or extracellular calcium release by thapsigargin or EGTA also block TNF‐induce calcium release in P. falciparum.
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Expression of the P. falciparum Proliferating‐Cell Nuclear Antigen 1 (PfPCNA1) decreased after P. falciparum treatment with TNF or 6‐Bnz cAMP.
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The data show that Plasmodium may subvert the immunological system and use TNF for the control of its proliferation within the vertebrate host.