Effects of aspirin on expression of iron transport and storage proteins in BV-2 microglial cells
详细信息 查看全文
- 作者：Yan Xin Xua ; 1 ; Fang Duc ; 1 ; Li Rong Jiangb ; Jing Gonga ; b ; Yu-Fu Zhoub ; Qian Qian Luob ; Zhong Ming Qiana ; b ; qianzhongming@fudan.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Ya Kec ; yake@cuhk.edu.hk" class="auth_mail" title="E-mail the corresponding author
- 关键词：Aspirin (acetylsalicylic acid ; ASA) ; Iron metabolism ; Inflammation and lipopolysaccharides (LPS) ; Transferrin receptor 1 (TfR1) ; Ferroportin 1 (Fpn1) ; Tumor necrosis factor-αlpha (TNF-alpha) ; Interleukin-6 (IL-6) ; Hepcidin
- 刊名：Neurochemistry International
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：91
- 期：Complete
- 页码：72-77
- 全文大小：998 K
文摘
- •
Aspirin protected BV-2 microglial cells from LPS-induced damage.
- •
Aspirin reduced TfR1 and increased Fpn1 and ferritin expression in BV-2 cells.
- •
Aspirin increased TfR1 and Fpn1 expression in LPS-treated BV-2 cells.
- •
Aspirin suppressed IL-6 and TNF-alpha mRNA expression in LPS-treated BV-2 cells.