The role of the Annexin-A1/FPR2 system in the regulation of mast cell degranulation provoked by compound 48/80 and in the inhibitory action of nedocromil
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- 作者：Ajantha Sinniahc ; Samia Yazida ; M. Perrettic ; Egle Solitob ; R.J. Flowerc ; r.j.flower@qmul.ac.uk" class="auth_mail" title="E-mail the corresponding author
- 关键词：Mast cell ; Cromones ; Compound 48/80 ; ANX-A1 ; PKC ; PP2A
- 刊名：International Immunopharmacology
- 出版年：2016
- 出版时间：March 2016
- 年：2016
- 卷：32
- 期：Complete
- 页码：87-95
- 全文大小：1062 K
文摘
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Mast cell ‘stabilisers’ release anti-inflammatory ANX-A1 from mast cells.
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Anti-ANX-A1 neutralising Mabs blocked their inhibitory effect.
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Mast cells from Anx-A1−/− mice are insensitive to nedocromil or ketotifen.
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The effect of ANX-A1 on PGD2 release depends upon the fpr2/3 receptor.
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ANX-A1, acting partly through FPR, is a key regulator of mast cell reactivity.