The cytokine-serum amyloid A-chemokine network
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- 作者：Mieke De Bucka ; mieke.debuck@rega.kuleuven.be" class="auth_mail" title="E-mail the corresponding authorAuthor Vitae ; Mieke Gouwya ; mieke.gouwy@rega.kuleuven.be" class="auth_mail" title="E-mail the corresponding authorAuthor Vitae ; Ji Ming Wangb ; wangji@mail.nih.gov" class="auth_mail" title="E-mail the corresponding authorAuthor Vitae ; Jacques Van Snickc ; d ; jacques.vansnick@bru.licr.org" class="auth_mail" title="E-mail the corresponding authorAuthor Vitae ; Paul Proosta ; paul.proost@rega.kuleuven.be" class="auth_mail" title="E-mail the corresponding authorAuthor Vitae ; Sofie Struyfa ; sofie.struyf@rega.kuleuven.be" class="auth_mail" title="E-mail the corresponding authorAuthor Vitae ; Jo Van Dammea ; jo.vandamme@rega.kuleuven.be" class="auth_mail" title="E-mail the corresponding authorAuthor Vitae
- 关键词：SAA ; FPR2 ; Chemotaxis ; Cytokines ; TLR2
- 刊名：Cytokine & Growth Factor Reviews
- 出版年：2016
- 出版时间：August 2016
- 年：2016
- 卷：30
- 期：Complete
- 页码：55-69
- 全文大小：1223 K
文摘
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Cytokines are potent inducers of serum amyloid A (SAA) in hepatocytes.
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SAA induces several cytokines and chemokines, mediating its biological functions.
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SAA induces chemokines via TLR2 whereas it directly chemoattracts leukocytes via FPR2.
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SAA synergizes with induced chemokines to enhance leukocyte migration.
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A cytokine-SAA-chemokine cascade is established during inflammation