Measuring longitudinal myelin water fraction in new multiple sclerosis lesions
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- 作者：Wendy S. Vargasa ; 1 ; Elizabeth Monohana ; 1 ; 2 ; Sneha Pandyad ; Ashish Rajb ; d ; Timothy Vartaniana ; b ; Thanh D. Nguyend ; Sandra M. Hurtado Rú ; ac ; 2 ; Susan A. Gauthiera ; b ; sag2015@med.cornell.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Multiple sclerosis ; MRI ; Myelin water fraction (MWF) ; Acute lesion ; Myelin
- 刊名：NeuroImage: Clinical
- 出版年：2015
- 出版时间：2015
- 年：2015
- 卷：9
- 期：Complete
- 页码：369-375
- 全文大小：731 K
文摘
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FAST-T2 can measure the extent of myelin loss within early MS lesions.
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The largest study utilizing an in-vivo MRI method to assess MS lesion change
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The majority of change occurs in the earliest stages after MS lesion development.
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The intensity of the acute inflammatory event is detrimental on MWF recovery.