Elution time changes due to anomalous DEP effects in microchannels under uniform and non-uniform electric fields

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• 作者：Antonino Magliano^a ; ^{maglianoantonino@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Massimo Camarda^a ; ^d ; Salvatore Francesco Lombardo^a ; Rossana Di Martino^c ; Michele Cascio^a ; Alessandra Romano^b ; Luigi Minafra^c ; Giorgio Russo^c ; Mariacarla Gilardi^c ; Francesco Di Raimondo^b ; Silvia Scalese^a ; Antonino La Magna^a
• 关键词：DEP ; dielectrophoresis ; FFF-DEP ; field flow fractionation DEP ; nDEP ; negative-DEP ; pDEP ; positive-DEP ; aDEP ; anomalous DEP ; MST ; Maxwell Stress Tensor ; MDA ; human cancer cells mb &mdash ; 231 triple negative ; LYM ; lymphocytes
• 刊名：Sensing and Bio-Sensing Research
• 出版年：2016
• 出版时间：May 2016
• 年：2016
• 卷：8
• 期：Complete
• 页码：59-64
• 全文大小：1454 K

文摘

Conventional dielectrophoresis (DEP) force on cell and particle is altered in the proximity of the electrodes due to the failure of the dipole approximation. In these conditions an anomalous DEP (aDEP) force rules the particle manipulation. Anyhow, the role of the aDEP is barely considered in the design of DEP devices. Here we analyze, using a multiscale simulation approach, the aDEP effects in micro-fluidic device coupled with interdigitated channel commonly used in continuous mode field flow fractionation dielectrophoretic (FFF-DEP) devices for the separation of circulating tumor cells (MDA) and Lymphocytes (LYM). We study the propagation of an injected density of MDA and LYM respectively and evaluate how the aDEP changes the migrations of the cells.