Asymmetrical flow field-flow fractionation coupled with multi-angle laser light scattering for stability comparison of virus-like particles in different solution environments
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- 作者：Yi Chena ; b ; 1 ; Yan Zhanga ; 1 ; Yuefang Zhoua ; Jian Luoa ; Zhiguo Sua ; c ; zgsu@ipe.ac.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Asymmetrical flow field-flow fractionation ; Virus-like particle ; Antigenicity ; Hepatitis B surface antigen ; Aggregation
- 刊名：Vaccine
- 出版年：2016
- 出版时间：8 June 2016
- 年：2016
- 卷：34
- 期：27
- 页码：3164-3170
- 全文大小：2421 K
文摘
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HBsAg particles expressed by CHO and Hansenula polymorpha were compared by AF4-MALLS.
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Stabilities of CHO-HBsAg and Hans-HBsAg under different solution environments were described.
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CHO-HBsAg was more homogeneous and more stable under different solution environments than Hans-HBsAg.