Biological properties of Hertia cheirifolia L. flower extracts and effect of the nopol on α-glucosidase

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• 作者：Kaouther Majouli^a ; ^{kaouther.bio@gmail.com} ; Mohamed Ali Mahjoub^b ; Fazal Rahim^c ; Assia Hamdi^d ; Abdul Wadood^e ; Malek Besbes Hlila^f ; Abderraouf Kenani^a
• 关键词：Antioxidant activity ; α-Glucosidase inhibition ; Molecular docking
• 刊名：International Journal of Biological Macromolecules
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：95
• 期：Complete
• 页码：757-761
• 全文大小：559 K
• 卷排序：95

文摘

In screening for antioxidant and α-glucosidase inhibitors from the extracts of Hertia cheirifolia L. flowers, the petroleum ether extract showed interesting antioxidant activity and inhibitory effect on the activity of α-glucosidase. The fractionation of this extract resulted in the isolation of a compound which is characterized by NMR and ESI–MS as a nopol. The nopol exhibited potent α-glucosidase inhibitory potential with IC50 value of 220 μM. The kinetic evaluation indicated that it acts as a non-competitive inhibitor. A molecular docking study proved that the nopol presented a strong affinity with amino acid residues of α-glucosidase.