Conditioned medium of periodontal ligament mesenchymal stem cells exert anti-inflammatory effects in lipopolysaccharide-activated mouse motoneurons
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- 作者：Thangavelu Soundara Rajana ; Sabrina Giacoppoa ; Oriana Trubianib ; Francesca Diomedeb ; Adriano Piattellib ; Placido Bramantia ; Emanuela Mazzona ; emazzon.irccs@gmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：ANOVA ; Analysis of variance ; Bcl-2 ; B-cell lymphoma 2 ; Bax ; Bcl-2 Associated X protein ; DMEM ; Dulbecco's modification of Eagle's medium Dulbecco ; ELISA ; Enzyme linked immunosorbent assay ; FBS ; Fetal bovine serum ; GAP43 ; Growth Associated Protein 43 ; HRP ; Horse radish peroxidase ; hPDLSCs ; Human periodontal ligament mesenchymal stem cells ; IκB-α ; Inhibitor of kappa B alpha ; IL-10 ; Interleukin 10 ; LPS ; Lipopolysaccharide ; MSCs ; Mesenchymal stem cells ; NGF ; Nerve growth factor ; NFL70 ; Neurofilament
- 刊名：Experimental Cell Research
- 出版年：2016
- 出版时间：15 November 2016
- 年：2016
- 卷：349
- 期：1
- 页码：152-161
- 全文大小：1191 K
文摘
- 5">
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5">hPDLSC-conditioned medium from RR-MS patients exert anti-inflammatory effects on neurons.
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Neuroprotective effect was elicited by hPDLSC-secretions in neurons.
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5">IL-10 and TGF-β present in EMVs of conditioned medium may induce immunomodulatory effects.