Distinct Trends of DNA Methylation Patterning in the Innate and Adaptive Immune Systems
详细信息 查看全文
- 作者：Ronald P. Schuyler1 ; 2 ; Angelika Merkel1 ; 2 ; Emanuele Raineri1 ; 2 ; Lucia Altucci3 ; Edo Vellenga4 ; Joost H.A. Martens5 ; Farzin Pourfarzad6 ; Taco W. Kuijpers6 ; 7 ; Frances Burden8 ; 9 ; Samantha Farrow8 ; 9 ; Kate Downes8 ; 9 ; Willem H. Ouwehand8 ; 9 ; 10 ; 11 ; Laura Clarke12 ; Avik Datta12 ; Ernesto Lowy12 ; Paul Flicek12 ; Mattia Frontini8 ; 9 ; 10 ; Hendrik G. Stunnenberg5 ; José ; I. Martí ; n-Subero13 ; Ivo Gut1 ; 2 ; Simon Heath1 ; 2 ; 14 ; simon.heath@gmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：DNA methylation ; epigenetics ; whole-genome bisulfite sequencing ; hematopoiesis ; CTCF ; nucleosomes ; BLUEPRINT
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：15 November 2016
- 年：2016
- 卷：17
- 期：8
- 页码：2101-2111
- 全文大小：3762 K
文摘
- •
Global trends in DNA methylation diverge in the lymphoid and myeloid lineages
- •
Methylation shifts from nucleosomes to linker DNA in developing lymphocytes
- •
Substantial non-CpG methylation occurs in naive T cells and many myeloid cancers
- •
Methylomes from many isolated cell types and stages provide a broad resource