Leukocytes Breach Endothelial Barriers by Insertion of Nuclear Lobes and Disassembly of Endothelial Actin Filaments

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• 作者：Sagi Barzilai¹ ; ⁶ ; Sandeep Kumar Yadav¹ ; ⁶ ; Steven Morrell² ; Francesco Roncato¹ ; Eugenia Klein³ ; Liat Stoler-Barak¹ ; Ofra Golani⁴ ; Sara W. Feigelson¹ ; Assaf Zemel⁵ ; Sussan Nourshargh² ; Ronen Alon¹ ; ⁷ ; ^{ronen.alon@weizmann.ac.il}
• 关键词：inflammation ; leukocyte trafficking ; adhesion ; migration ; shear flow ; vasculature
• 刊名：Cell Reports
• 出版年：2017
• 出版时间：17 January 2017
• 年：2017
• 卷：18
• 期：3
• 页码：685-699
• 全文大小：6347 K
• 卷排序：18

文摘

Leukocytes generate micron-scale gaps when squeezing through inflamed vessels Gap formation by squeezing leukocytes does not require endothelial contractility Transmigrating T cells deform and insert nuclear lobes into their lamellipodia These lobes bend endothelial stress fibers and disassemble the thinner actin filaments