Cocaine and ethanol target 26 S proteasome activity and gene expression in neuroblastoma cells
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- 作者：Francesca Felicia Caputi ; francesca.caputi3@unibo.it" class="auth_mail" title="E-mail the corresponding author ; Lucia Carboni ; Daria Mazza ; Sanzio Candeletti ; Patrizia Romualdi
- 关键词：Cocaine ; Ethanol ; Proteasome activity ; Subunit gene expression ; SH-SY5Y
- 刊名：Drug and Alcohol Dependence
- 出版年：2016
- 出版时间：1 April 2016
- 年：2016
- 卷：161
- 期：Complete
- 页码：265-275
- 全文大小：2123 K
文摘
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Addictive substances regulate proteasome activity and expression in SH-SY5Y cells.
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Cocaine increased and ethanol reduced proteasome chymotrypsin-like activity.
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Cocaine increased the β1, α5 and Rpt3 mRNAs, while it reduced α6 transcripts.
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Ethanol augmented β1, β2 and α5 mRNAs, whereas it decreased Rpt3 gene expression.
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Subunit alterations may cause structural changes affecting the proteasome complex.