- 作者：Pietro Ferrara ; Valerio Romano ; Ivana Cortina ; Francesca Ianniello ; Giovanna Carmela Fabrizio ; Antonio Chiaretti
- 关键词：Enuresis ; Fast-melting oral desmopressin lyophilisate ; Treatment
- 刊名：Journal of Pediatric Urology
- 出版年：February, 2014
- 年：2014
- 卷：10
- 期：1
- 页码：52-55
- 全文大小：214 K
Objective
To investigate whether a structured withdrawal program from a sublingual formulation of fast-melting oral desmopressin lyophilisate (MELT) is superior to a sudden withdrawal from this formulation in the treatment of monosymptomatic nocturnal enuresis.Materials and methods
One hundred and three children presented to our pediatric nephrology outpatient clinic for bedwetting. Eighty-one children, aged between 5陆 and 14 years (mean age 8.64 years), were treated with MELT at a dosage of 120聽mcg a day. Responders were randomized to been withdrawn from therapy, after 3 months, abruptly or in a structured withdrawal program (60聽mcg/day for 15 days and then 60聽mcg every second evening for another 15 days).
Main outcome parameter was relapse rate 1 month after the end of treatment. Relapse was defined as bedwetting occurring more than 2 nights per month after the 1-month treatment-free period.
Results
Relapse rate at 1 month after the end of treatment was 47.83% in the group on a structured program versus 45.83% in the abrupt termination group (p聽=聽0.89).
Conclusion
Our study suggests that a structured withdrawal program from MELT therapy doesn't offer advantages compared to an abrupt termination in children with monosymptomatic nocturnal enuresis.