¹³C-octanoic acid breath test (OBT) with a new test meal (EXPIROGer^®): Toward standardization for testing gastric emptying of solids

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• 作者：Francesco Perri ; Massimo Bellini ; Piero Portincasa ; Andrea Parodi ; Patrizia Bonazzi ; Leonardo Marzio ; Francesca Galeazzi ; Paolo Usai ; Attilio Citrino ; Paolo Usai-Satta
• 关键词：Dyspepsia ; Gastric emptying ; Motility disorders ; Octanoic acid breath test ; Stable isotope
• 刊名：Digestive and Liver Disease
• 出版年：2010
• 出版时间：August 2010
• 年：2010
• 卷：42
• 期：8
• 页码：549-553
• 全文大小：403 K

文摘

Background

Standardization of the ¹³C-octanoic acid breath test is still lacking.

Aim

To evaluate the accuracy of the ¹³C-octanoic acid breath test using a new standardized ready-to-eat, gluten-, glucose-, and lactose-free muffin.

Methods

Healthy subjects were recruited and sorted by sex and age. Patients with diabetic gastroparesis and untreated celiac disease with known gastric motility disorders were also tested with the new labelled muffin. Expired breath ¹³CO₂ was analysed and t_1/2 was calculated.

Results

Overall, 131 healthy subjects were enrolled. The reference range of t_1/2 was 88 ± 29 min with the value of 146 min as the upper limit of normal range. No significant difference in t_1/2 was found among subjects sorted by sex or age. The within-subject variability of t_1/2 was 17 % . Mean (±standard deviation) t_1/2 values were 179 ± 50 min in patients with diabetic gastroparesis (n = 8) and 151 ± 20 min in those with untreated celiac disease (n = 11) (p ≤ 0.001 vs controls).

Conclusions

A new standardized test meal simplifies the execution of the ¹³C-octanoic acid breath test, is not influenced by sex or age, has low intra-individual variability, is palatable, does not cause side effects, and is able to evaluate gastric emptying in both patients and healthy controls. Moreover, it can be used in subjects with lactose intolerance, diabetes, and celiac disease.