Structural aspects of multi-domain RING/Ubox E3 ligases in DNA repair

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• 作者：Richard G. Hibbert ; Francesca Mattiroli ; Titia K. Sixma
• 关键词：Ubiquitin ; RING finger ; Ubox ; Ubiquitin ligase ; Ligase structure ; DNA repair
• 刊名：DNA Repair
• 出版年：2009
• 出版时间：5 April 2009
• 年：2009
• 卷：8
• 期：4
• 页码：525-535
• 全文大小：1554 K

文摘

Ubiquitin conjugation plays critical roles in virtually all DNA repair pathways. This review provides an overview of the known multi-domain RING/Ubox E3 ligases and their domain structures. An analysis of known RING/Ubox X-ray and NMR structures leads to a discussion of the effects of dimerization. Structural and mechanistic data relating to the E3 ligase preferences for E2 interaction and chain-type specificity are reviewed and the role of the E3 ligases in regulation of the repair pathways is discussed.