Impact of variations in triage cytology interpretation on human papillomavirus-based cervical screening and implications for screening algorithms
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- 作者：Guglielmo Roncoa ; guglielmo.ronco@cpo.it" class="auth_mail" title="E-mail the corresponding author ; Marco Zappab ; Silvia Franceschic ; Sara Tunesia ; d ; Adele Caprioglioa ; Massimo Confortinib ; Annarosa Del Mistroe ; Francesca Carozzib ; Nereo Segnana ; Manuel Zorzif ; Paolo Giorgi-Rossig ; h ; the Italian HPV Survey Working Group1 ; A. Gillio Tosi ; P. Giubilatoi ; L. Pasqualej ; G. Lucianoj ; E. Pollak ; P. Dalla Palmak ; C. Fedatol ; F. Zagom ; A. Pupon ; I. Simoncelloo ; M.G. Penonp ; L. Galloq ; A. Del Soler ; L. Paterlinis ; C. Camparis ; A. Iossat ; A. Barcau ; M.C. Tufiv ; P. Bellardiniw ; C. Fortunatox ; M. Minnay ; A. Macerolaz ; D. Caraceniaa
- 关键词：Human papillomavirus ; Cervical cancer ; Screening ; Triage ; Cytology
- 刊名：European Journal of Cancer
- 出版年：2016
- 出版时间：November 2016
- 年：2016
- 卷：68
- 期：Complete
- 页码：148-155
- 全文大小：385 K
文摘
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Human papillomavirus (HPV)-based screening needs triage of HPV+ women. To date reflex cytology is applied.
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Usually HPV test is repeated in HPV+/cytology-normal women.
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In routine implementation, in 10 programmes, 20–57% of HPV-positive women were judged to have abnormal cytology.
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This large variability affects only marginally the overall colposcopy referral.
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The sensitivity of reflex cytology only marginally affects overall sensitivity.