Oxidative stress-mediated arterial dysfunction in patients with metabolic syndrome: Effect of ascorbic acid

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• 作者：Roberto Cangemi ; Francesco Angelico ; Lorenzo Loffredo ; Maria Del Ben ; Pasquale Pignatelli ; Aless ; ra Martini ; Francesco Violi
• 关键词：Metabolic syndrome ; Oxidative stress ; Flow-mediated dilation ; Ascorbic acid ; Free radicals
• 刊名：Free Radical Biology and Medicine
• 出版年：2007
• 出版时间：1 September 2007
• 年：2007
• 卷：43
• 期：5
• 页码：853-859
• 全文大小：248 K

文摘

Arterial dysfunction is a hallmark of early atherosclerosis; however, its behavior in patients with metabolic syndrome (MS) is still unclear. We investigated the role of oxidative stress on ischemia-induced flow-mediated dilatation (FMD) in patients with MS. FMD and oxidative stress, as assessed by serum levels of 8-hydroxy-2-deoxy-2-deoxyguanosine (8-OHdG), were studied in 18 MS and 30 control subjects. Thereafter, in the 18 MS patients, FMD was assessed after iv infusion of 1 g vitamin C or placebo in a randomized, double-blind, crossover design; serial blood samples were taken in peripheral circulation before and after FMD to analyze 8-OHdG. Compared to controls, MS patients had higher 8-OHdG (p < 0.001) and lower FMD (p < 0.001); 8-OHdG and FMD were inversely correlated (R = −0.74; p < 0.01). In MS patients, placebo administration did not change FMD, whereas vitamin C significantly enhanced it (p < 0.001). After placebo, ischemia-induced FMD was associated with a significant increase in 8-OHdG (p < 0.001), an effect that was counteracted by vitamin C. Vitamin C infusion was associated with an inverse correlation between the changes in FMD and oxidative stress (R = −0.67; p < 0.01). The present study shows that arterial dilatation is impaired and that enhanced oxidative stress may play a key role in patients with MS.