Microparticles derived from endothelial progenitor cells in patients at different cardiovascular risk

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• 作者：Matteo Pirro ; Giuseppe Schillaci ; Francesco Bagaglia ; Cinzia Menecali ; Rita Paltriccia ; Massimo R. Mannarino ; Marusca Capanni ; Andrea Velardi ; Elmo Mannarino
• 关键词：Endothelial progenitor cells ; Microparticles ; Cardiovascular risk factors ; Arterial stiffness
• 刊名：Atherosclerosis
• 出版年：2008
• 出版时间：April 2008
• 年：2008
• 卷：197
• 期：2
• 页码：757-767
• 全文大小：737 K

文摘

Exposure to cardiovascular risk factors causes the release of pro-atherogenic microparticles from vascular cells and reduces the number of the atheroprotective endothelial progenitor cells (EPCs). We investigated whether microparticles shedding from EPCs are detectable in cultures of EPCs and in the circulation of subjects with various degrees of cardiovascular risk. We also investigated the relationship of EPCs-derived microparticles to cardiovascular risk factors and aortic stiffness, a marker of cardiovascular risk and impaired vascular repair by EPCs.