Necrotizing skin lesion and radial nerve palsy in a patient treated with glatiramer acetate
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- 作者：Antonio Carotenuto ; Rosa Iodice ; Francesco Barbato ; Nicola Salvatore Orefice ; Giuseppe Orefice
- 关键词：Glatiramer acetate ; Radial nerve palsy ; Necrotizing lesion ; Multiple sclerosis ; Skin reaction ; Autoimmune diseases
- 刊名：Journal of the Neurological Sciences
- 出版年：2013
- 出版时间：15 August, 2013
- 年：2013
- 卷：331
- 期：1-2
- 页码：172-173
- 全文大小：344 K
文摘
Glatiramer acetate (GA) is an approved and well tolerated drug for the treatment of relapsing-remitting multiple sclerosis. We report a case of a 52 year-old man with psoriasis and relapsing-remitting multiple sclerosis who developed, after 21 months of GA treatment, an injection-site cutaneous necrosis that involved both subcutaneous and muscular tissue with massive edema, followed, 3 days later, by radial nerve palsy. After few days another similar lesion appeared in another injection-site. We hypothesize that cutaneous necrosis could be due to a local dis-immune reaction and, probably, psoriasis could have played an important role in its pathogenesis.