Aspirin-mediated acetylation of haemoglobin increases in presence of high glucose concentration and decreases protein glycation
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- 作者：Francesco Finamorea ; Feliciano Priego-Capoteb ; Severine Nollic ; Pierre Fontanac ; Jean-Charles Sancheza ; Jean-Charles.Sanchez@unige.ch" class="auth_mail" title="E-mail the corresponding author
- 关键词：Protein glycation ; Aspirin-mediated acetylation ; Red blood cells ; Haemoglobin ; Mass spectrometry ; Label-free
- 刊名：EuPA Open Proteomics
- 出版年：2015
- 出版时间：September 2015
- 年：2015
- 卷：8
- 期：Complete
- 页码：116-127
- 全文大小：1576 K
文摘
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The state of aspirin-acetylation and glycation was investigated on red blood cells.
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A mass spectrometry approach allowed the accurate elucidation of protein sites.
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The levels of acetylation and glycation were quantified on haemoglobin.
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Diagnostic based on HbA1c test may be biased by the presence of aspirin.