Coupled plasma filtration adsorption improves hemodynamics in septic shock

详细信息    查看全文

• 作者：Matteo Franchi ; MD^a ; ^{matteoals@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Marilù ; Giacalone ; MD^a ; ^{marilugiacalone@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Ippolito Traupe ; MD^a ; ^{ippolito82@hotmail.it" class="auth_mail" title="E-mail the corresponding author} ; Rocco Rago ; MD^b ; ^{r.rago@ao-pisa.toscana.it" class="auth_mail" title="E-mail the corresponding author} ; Giacomo Baldi ; MD^a ; ^{giacomo.baldi@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Francesco Giunta ; MD^a ; ^b ; ^{fgiunta@med.unipi.it" class="auth_mail" title="E-mail the corresponding author} ; Francesco Forfori ; MD^a ; ^b ; ^{francescoforfori@gmail.com" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Septic shock ; CPFA ; Hemodynamics ; Cytokines ; Multiple organ failure
• 刊名：Journal of Critical Care
• 出版年：2016
• 出版时间：June 2016
• 年：2016
• 卷：33
• 期：Complete
• 页码：100-105
• 全文大小：466 K

文摘

Septic shock involves a dysregulation of the immune response to an infection. This may lead to hemodynamic dysfunction and multiple-organ failure. The main aim of this study was to evaluate the effect of coupled plasma filtration adsorption (CPFA) on the hemodynamic profile in patients with septic shock.

Materials and methods

We retrospectively analyzed data from 21 adult patients admitted to the intensive care unit with a diagnosis of septic shock, comparing data between pre-CPFA and post-CPFA treatment. They received a maximum of 5 cycles of treatment.

Results

Coupled plasma filtration adsorption treatment was associated with a significant increase of mean arterial pressure (P < .001), reduction of the vasoactive/inotropic requirement (P = .007), and renal improvement. In patients with leukocytosis or leucopenia, the leukocyte count was restored to a reference range of values.

Conclusion

Treatment with CPFA improves hemodynamic parameters in septic shock patients, ameliorating organ failure.