Wide tolerance to amino acids substitutions in the OCTN1 ergothioneine transporter
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- 作者：Marta Frigenia ; Francesco Iacobazzia ; b ; Xue Yina ; Nicola Longoa ; Nicola.Longo@hsc.utah.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Ergothioneine transport ; OCTN1 ; SLC22A4 ; OCTN2 ; SLC22A5 ; Organic cation transporters
- 刊名：Biochimica et Biophysica Acta (BBA) - General Subjects
- 出版年：2016
- 出版时间：June 2016
- 年：2016
- 卷：1860
- 期：6
- 页码：1334-1342
- 全文大小：1409 K
文摘
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The SLC22A4 gene encodes the OCTN1 (ergothioneine) transporter.
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Variations in the SLC22A4 gene have been associated with autoimmune disorders.
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Chimeric OCTN1/OCTN2 transporters transported ergothioneine more efficiently than wild-type OCTN1.
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Single amino acid substitutions also increased OCTN1 activity.
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Unlike the OCTN2 carnitine transporter, the OCTN1 ergothioneine transporter is tolerant to extensive amino acid substitutions.