Effect of dietary supplementation with glucomannan on plasma total cholesterol and low density lipoprotein cholesterol in hypercholesterolemic children

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• 作者：Francesco Martino ; Eliana Martino ; Francesco Morrone ; Elisabetta Carnevali ; Roberta Forcone ; Tarcisio Niglio
• 关键词：Glucomannan ; Plasma hypercholesterolemia ; Diet ; Children
• 刊名：Nutrition, Metabolism and Cardiovascular Diseases
• 出版年：2005
• 出版时间：June 2005
• 年：2005
• 卷：15
• 期：3
• 页码：174-180
• 全文大小：101 K

文摘

This paper evaluates the effect of the adjunct of the hydrosoluble fiber glucomannan to a Step-One-Diet in 40 plasma hypercholesterolemic children, during a randomized controlled trial, to reduce plasma cholesterol.

Methods

All the subjects recruited underwent an 8-week run in diet period; a Step-One-Diet was prescribed. After that, they were randomly allocated to one of two groups: Step-One-Diet only (control), and Step-One-Diet plus glucomannan in gelatine capsules. After another 8 weeks of treatment, the results were compared within and between the two groups.

Results

Glucomannan treated group showed decreased values in plasma total cholesterol (TC) and low density lipoprotein cholesterol (LDL-C) vs. control group after 8 weeks of treatment. The percentage decrease showed a statistically significant difference between sex groups. Decreases were observed in favor of female vs. male children in TC (24 % vs. 9 % ) and LDL-C (30 % vs. 9 % ).

Conclusions

These results suggest that glucomannan may represent a rationale adjunct to diet therapy in primary prevention in high risk hypercholesterolemic children.