Heroin sensitization as mapped by c-Fos immunoreactivity in the rat striatum
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- 作者：D’ ; Este ; Loredana ; Scontrini ; Alessandra ; Casini ; Arianna ; Pontieri ; Francesco E. ; Renda ; Tindaro G.
- 关键词：Neural basis of behavior ; Drugs of abuse ; opioids and others ; c-Fos oncoprotein ; Heroin ; Sensitization ; Caudate-putamen ; Nucleus accumbens shell ; Immunohistochemistry
- 刊名：Brain Research
- 出版年：2002
- 出版时间：April 19, 2002
- 年：2002
- 卷：933
- 期：2
- 页码：144-149
- 全文大小：894 K
文摘
Immunohistochemistry was used to map the induction of c-Fos protein in the forebrain of rats treated with heroin. Acute injection of heroin to drug-naive rats caused significant induction of c-Fos protein in the nucleus accumbens shell, whereas the same dose of heroin given to drug-sensitized rats significantly increased c-Fos immunoreactivity in the dorsomedial caudate-putamen. These results show that the heroin-induced pattern of c-Fos protein in the rat striatum differs according to the rat’s drug history. These findings may represent a neural correlate of the motor components of heroin sensitization.