Melatonin influences NO/NOS pathway and reduces oxidative and nitrosative stress in a model of hypoxic-ischemic brain damage

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• 作者：Santos Blanco^a ; ^{sblanco@ujaen.es} ; Raquel Herná ; ndez^a ; ^{rhernand@ujaen.es} ; Gustavo Franchelli^a ; ^{r6.gustavo@gmail.com} ; Manuel Miguel Ramos-Á ; lvarez^b ; ^{mramos@ujaen.es} ; Marí ; a Á ; ngeles Peinado^a ; ^{apeinado@ujaen.es}
• 关键词：Melatonin ; Nitric oxide ; Ischemia ; Hypobaric hypoxia ; Antioxidant ; oxidative and nitrosative stress
• 刊名：Nitric Oxide
• 出版年：2017
• 出版时间：30 January 2017
• 年：2017
• 卷：62
• 期：Complete
• 页码：32-43
• 全文大小：1912 K
• 卷排序：62

文摘

The ischemic/hypoxic (IH) model applied in this study deregulates the NO/NOS pathway. Melatonin prompts nNOS response after IH. Melatonin downregulates iNOS and diminishes nitrosative-oxidative impacts after IH. Melatonin may prevent HI neurodegenerative associated damage via NO/NOS balance. Melatonin is a suitable standard for studying the molecular mechanisms underlying IH.