• 作者：Alberto Cordero^a ; ^{acorderofort@gmail.com} ; Vicente Bertomeu-Mart&#237 ; nez^a ; Pilar Mazó ; n^b ; Enrique Galve^c ; Iñ ; aki Lekuona^d ; Fernando de la Gu&#237 ; a^e ; Juan Cos&#237 ; n^f ; José ; Garc&#237 ; a Gó ; mez^g ; Francisco Roncales^h ; José ; Ramó ; n Gonzá ; lez-Juanatey^b
• 关键词：S&iacute ; ndrome coronario agudo ; Tabaquismo ; Edad ; Complicaciones hospitalarias
• 刊名：Medicina Cl¨ªnica
• 出版年：2012
• 出版时间：21 April, 2012
• 年：2012
• 卷：138
• 期：10
• 页码：422-428
• 全文大小：316 K

Background and objective

Current smoking patients with acute coronary syndromes (ACS) seem to have better prognosis during hospital stay. The objective of this study was to describe the clinical characteristics and complications of patients with ACS according to smoking habits.

Patients and methods

Observational, multicentre and nationwide registry. Primary endpoint was hospital mortality and secondary endpoint was the combination of mortality, angina or heart failure.

Results: 825 ACS patients were collected. Current smokers were 413 (50.1 % ) and their mean age was 12 years lower than the rest and also had lower prevalence of risk factors or previous cardiovascular disease. Complications and mortality were similar according to smoking habits. Multivariate adjusted analysis identified age > 75 (OR: 12.80, 95 % CI 1.35-41.44; p = 0.03) and GFR < 60 ml/min/1.73 m² (OR: 10.20, 95 % CI 1.06-97.92; p = 0.04) independently associated with mortality; age > 75 (OR: 1.72, 95 % CI 1.03-2.84; p = 0.04), GFR < 60 ml/min/1.73 m² (OR: 1.76, 95 % CI 1.08-2.91; p = 0.023) and current smoking (OR: 1.05, 95 % CI 1.01-1.10; p = 0.02) were independently associated with the combined end-point. Elderly current smokers patients had the highest mortality rate (19.0 % ) followed by elderly former smokers patients (5.8 % ).

Conclusions

Current smoker patients with ACS have lower mean age and have similar hospital complications.