Improving linezolid use decreases the incidence of resistance among Gram-positive microorganisms

详细信息    查看全文

• 作者：Elena Ramí ; rez^a ; ^{elena.ramirez@uam.es} ; Rosa Gó ; mez-Gil^b ; Alberto M. Borobia^a ; Francisco Moreno^c ; Claudia Zegarra^a ; Raú ; l Mu&#241 ; oz^a ; Zaida Reutero^b ; Carolina de Montreuil^b ; Diana Gonzá ; lez^c ; Sonsoles Herná ; ndez^c ; Alicia Herrero^c ; Avelino Gutié ; rrez^b ; Jesú ; s Frí ; as^a ; ^{jesus.frias@uam.es}
• 关键词：Linezolid ; Resistance ; Appropriateness of use ; Consumption ; Gram-positive ; Linezolid use
• 刊名：International Journal of Antimicrobial Agents
• 出版年：2013
• 出版时间：February, 2013
• 年：2013
• 卷：41
• 期：2
• 页码：174-178
• 全文大小：419 K

文摘

Surveillance studies have shown the emergence of infections with linezolid-resistant bacteria. The relationship between appropriate linezolid use and the spread of linezolid resistance among Gram-positive microorganisms in a single tertiary referral centre was evaluated. In an initial observational study, a prospective prescription-indication study was conducted on intensive care areas and haematology, neurosurgery, vascular surgery and nephrology wards during 2009. An intervention through follow-up feedback on audit results from May-June 2010 was then conducted. From July-December 2010, a second drug-use study of linezolid was conducted, with the same objectives and methodology. To assess the antimicrobial pressure of linezolid, an ecological study was conducted from 2006-2010 in the same hospital wards. Indications for linezolid in the initial study were considered suitable in 38.5 % of cases, whilst in the second study the rate was 51.2 % (33 % increase). Linezolid consumption fell by 57 % in the second half of 2010. A significant correlation was found between its inadequate use (DDD/1000 patient-days) and the incidence of linezolid-resistant strains/1000 patient-days (r = 0.93; P = 6.9e-024); 85 % of the variability in the incidence of linezolid resistance was predicted by its inadequate use. Its partial correlations were significant for Enterococcus faecium (r = 0.407; P = 0.049), Staphylococcus epidermidis (r = 0.874; P = 2.3e-008) and Staphylococcus haemolyticus (r = 0.406; P = 0.049) but not Staphylococcus aureus (r = 0.051; P = 0.704). A relationship was found between appropriate linezolid use and the incidence of linezolid-resistant strains of E. faecium, S. epidermidis and S. haemolyticus.