Maslinic acid derivatives induce significant apoptosis in b16f10 murine melanoma cells

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• 作者：Andres Parra ; ^{aparra@ugr.es} ; Francisco Rivas ; ^{frivas@ugr.es} ; Samuel Martin-Fonseca ; Andres Garcia-Granados ; Antonio Martinez
• 关键词：Maslinic acid derivatives ; Synthesis ; Cytotoxicity ; Anticancer activity ; Apoptosis
• 刊名：European Journal of Medicinal Chemistry
• 出版年：2011
• 出版时间：December, 2011
• 年：2011
• 卷：46
• 期：12
• 页码：5991-6001
• 全文大小：1438 K

文摘

Maslinic acid (2¦Á,3¦Â-dihydroxyolean-12-en-28-oic acid), a natural dihydroxylated pentacyclic triterpene acid isolated from olive-pressing residues, has been investigated together with some of its derivatives regarding the induction of apoptosis in B16F10 melanoma cells. Some of the compounds tested are described in this work, but others come from previous studies. Ten of these derivatives induce over 80 % of apoptosis, clearly promoting cell death in B16F10 melanoma. By contrast, the induction cell death through necrosis was very slightly significant with these compounds. These results indicate that maslinic acid derivatives are promising chemopreventive and chemotherapeutic agents.