The nitric oxide synthase expression of rat cortical and hippocampal neurons changes after early lead exposure

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• 作者：Selvin-Testa ; Asia ; Capani ; Francisco ; Loidl ; C. Fabiá ; n ; Pecci-Saavedra ; Jorge
• 关键词：Nitric oxide ; Neurotoxicity ; Development ; Cerebral cortex ; Hippocampus ; Learning disabilities
• 刊名：Neuroscience Letters
• 出版年：1997
• 出版时间：October 31, 1997
• 年：1997
• 卷：236
• 期：2
• 页码：75-78
• 全文大小：1.07 M

文摘

The effect of lead exposure in nitric oxide synthase containing neurons (nNOS) within rat cortex and hippocampus was studied. Lead administration (1 g % lead acetate in drinking water) was commenced prior to mating and continued until 30 postnatal (PN) days. Immunohistochemical studies using antibody to nNOS showed, after lead treatment at PN21-PN30, a reduction in neuronal size and optical density (OD) of nNOS+ cells. In both regions, non-pyramidal immunoreactive neurons exhibited smaller soma size and less developed dendrites. A significant differences in cell areas and OD of lead exposed versus control rats and no variation in the number of nNOS+ neurons was seen. Morphological modifications after early lead exposure, induced nNOS reduction in NOS expressing neurons thereby interfering in NO synthesis.