Conformational analysis of N-Boc-N,O-isopropylidene-α-serinals. A combined DFT and NMR study
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- 作者：Avenoza ; Alberto ; Busto ; Jesú ; s H. ; Corzana ; Francisco ; Jimé ; nez-Osé ; s ; Gonzalo ; et. al.
- 关键词：Garner's aldehyde ; density-functional theory ; dipole moment
- 刊名：Tetrahedron
- 出版年：2003
- 出版时间：July 21, 2003
- 年：2003
- 卷：59
- 期：30
- 页码：5713-5718
- 全文大小：571 K
文摘
This work describes an extensive conformational analysis of Garner's aldehyde and its α-methylated homologue—two important chiral building blocks that are widely used in organic synthesis. A combination of density-functional theory and NMR spectroscopy confirmed the existence of a dynamic equilibrium between two possible conformers of the carbamate group in these compounds. The calculated properties such as conformer populations and rotational barriers around the (C
O)–N bond are in good agreement with the experimental values. Finally, the dipole moments of the molecules appear to be a decisive factor in the stabilization of the conformers in solution.
O)–N bond are in good agreement with the experimental values. Finally, the dipole moments of the molecules appear to be a decisive factor in the stabilization of the conformers in solution.