Dopamine modulation affects the performance of parkinsonian patients in a precision motor task measured by an antropomorphic device
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- 作者：Cristina Nombela ; Juan Luis Pedre?o-Molina ; Francisco Ros-Bernal ; Javier Molina-Vilaplana ; Emiliano Fdez-Villalba ; Juan L¨®pez-Coronado ; Mar¨ªa-Trinidad Herrero
- 关键词：2330 ; 3297 ; 4010 ; 4140
- 刊名：Human Movement Science
- 出版年：2012
- 出版时间：June, 2012
- 年：2012
- 卷：31
- 期：3
- 页码：730-742
- 全文大小：718 K
文摘
Several parameters related to the timing, grip force and load force involved in a precision grasping task were studied in patients with Parkinson¡¯s disease (PD) at different moments of medication and healthy controls, using a sensorized anthropomorphic device which was totally adapted to the human hand. The aim of this work was to carry out an accurate study of the reach-load-grip-hold-place-release subtasks to identify any physical motor impairment, its relation to medication and Parkinsonian strategies. Twenty seven patients in ON and OFF-like medication moments, and twenty seven age-matched controls took part in the experiment, which consisted of using the index finger and the thumb to perform a precision motor task involving different experimental objects. Visual cues were used as distracting elements. Results showed several motor parameters impaired in OFF-like medication moment but attenuated in ON state, suggesting a medication effect on the performance of the task.