A new synthesis of combretastatins A-4 and AVE-8062A

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• 作者：Francisco Lara-Ochoa ; Georgina Espinosa-Pé ; rez
• 关键词：Salophen ; Oxamate ; Dissymmetric ligands ; Dinuclear complexes
• 刊名：Tetrahedron Letters
• 出版年：2007
• 出版时间：24 September 2007
• 年：2007
• 卷：48
• 期：39
• 页码：7007-7010
• 全文大小：177 K

文摘

Combretastatins A-4 and AVE-8062A have been synthesized by coupling 3,4,5-trimethoxyphenylacetylene with the corresponding iodomethoxyphenol and bromomethoxyaniline, followed by hydrolysis of the thermally-stable Ti(II)–alkyne complexes.