Safety of Thrombolytic Therapy for Acute Ischemic Stroke after Recent Transient Ischemic Attack

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• 作者：James S. McKinney ; Jaime Masjuan ; Francisco Purroy ; David Calvet ; Hakan Ay ; Brett L. Cucchiara
• 关键词：Hemorrhage ; stroke ; thrombolysis ; tissue plasminogen activator ; transient ischemic attack
• 刊名：Journal of Stroke and Cerebrovascular Diseases
• 出版年：2012
• 出版时间：October, 2012
• 年：2012
• 卷：21
• 期：7
• 页码：551-554
• 全文大小：66 K

文摘

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Background

The objective of this study was to assess the rate of symptomatic intracerebral hemorrhage (SICH) in patients given thrombolytic therapy for acute ischemic stroke (AIS) after recent transient ischemic attack (TIA).

Methods

This was a multicenter study of patients with confirmed TIA within 7 days before an AIS that was treated with intravenous (IV), intra-arterial (IA), or mechanical thrombolysis. A total of 23 cases were identified.

Results

The median time interval between index TIA and AIS was 9 hours. The median National Institutes of Health Stroke Scale score at the time of AIS was 12. The median time interval between stroke onset and thrombolytic treatment was 90 minutes. Thrombolytic therapies included IV thrombolysis (70 % ), IA thrombolysis (17 % ), IA and mechanical thrombolysis (9 % ), and IV followed by IA and mechanical thrombolysis (4 % ). The rate of postthrombolysis SICH in this group was 8.6 % (2/23).

Conclusions

The rate of SICH in our cohort appears similar to overall postthrombolysis hemorrhage rates.