Ru-catalyzed CH functionalization of phenylglycine derivatives: Synthesis of isoquinoline-1-carboxylates and isoindoline-1-carboxylates

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• 作者：Sara Ruiz ; Francisco J. Sayago ; Carlos Cativiela ; Esteban P. Urriolabeitia ; ^{esteban@unizar.es}
• 关键词：Ru-complexes ; Amino acids ; CH activation ; Isoquinolines ; Isoindolines
• 刊名：Journal of Molecular Catalysis A: Chemical
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：426
• 期：part_PB
• 页码：407-418
• 全文大小：2463 K
• 卷排序：426

文摘

N-unprotected phenylglycine derivatives have been functionalized selectively. Functionalization is catalyzed by Ru(II) complexes through oxidative coupling. Isoquinoline-1-carboxylates are obtained by coupling with internal alkynes. Isoindoline-1-carboxylates are obtained by coupling with methylacrylates.