Synthesis and antiviral evaluation of 2′,2′,3′,3′-tetrafluoro nucleoside analogs

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• 作者：Ozkan Sari^a ; Leda Bassit^a ; Christina Gavegnano^a ; Tamara R. McBrayer^b ; Louise McCormick^a ; Bryan Cox^a ; Steven J. Coats^b ; Franck Amblard^a ; Raymond F. Schinazi^a ; ^{rschina@emory.edu}
• 关键词：Nucleoside ; Prodrug ; Antiviral ; Fluorine ; Mitsunobu
• 刊名：Tetrahedron Letters
• 出版年：2017
• 出版时间：15 February 2017
• 年：2017
• 卷：58
• 期：7
• 页码：642-644
• 全文大小：876 K
• 卷排序：58

文摘

The synthesis of novel 2′,2′,3′,3′-tetrafluoro nucleoside analogs is described. Glycosylation reactions are achieved via Mitsunobu coupling. Energetics of ring conformation are compared to differently substituted ribose. Evaluation of Tetrafluoro nucleosides in vitro against a panel of DNA and RNA viruses.